Class A Orphans in GtoPdb v.2022.3

Table 1 lists a number of putative GPCRs identified by NC-IUPHAR [161], for which preliminary evidence an endogenous ligand has been published, or there exists potential link to disease, disorder. These have recently reviewed in detail [121]. The are all Class A, rhodopsin-like GPCRs. A orphan not listed with as-yet unidentified ligands.Table 1: ligands GPR3GPR4GPR6GPR12GPR15GPR17GPR20 GPR22GPR26GPR31GPR34GPR35GPR37GPR39 GPR50GPR63GPR65GPR68GPR75GPR84GPR87 GPR88GPR132GPR149GPR161GPR183LGR4LGR5 LGR6MAS1MRGPRDMRGPRX1MRGPRX2P2RY10TAAR2 In addition the receptors GPR18, GPR55 and GPR119 reported respond agents analogous cannabinoid grouped together (GPR18, GPR119).